ncRNA name | PKR siRNA |
ncRNA Category | siRNA |
Disease name | choroidal neovascularization (CNV) |
Species | Macaca mulatta |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | siRNA transfection, in vitro tube formation assay, Western blot, immunofluorescence, Fundus fluorescein angiography |
Expression pattern | associated |
Functional description | PKR promotes CNV formation via the PI3K/Akt signaling pathway in VEGF expression.In the ARPE-19 (RPE cell line) and RF/6A cell coculture system, PKR siRNA reduced the migration and tube formation of the RF/6A cells. |
PubMed ID | 27994435 |
Year | 2016 |
Title | PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.